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. 2007 Mar;9(1):3-10.
doi: 10.1111/j.1399-3062.2006.00172.x.

Non-bacterial infections in allogeneic non-myeloablative stem cell transplant recipients

S Narreddy  1 , S Mellon-Reppen, M H Abidi, J L Klein, E Peres, L K Heilbrun, D Smith, G Alangaden, P H Chandrasekar
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Non-bacterial infections in allogeneic non-myeloablative stem cell transplant recipients

S Narreddy et al. Transpl Infect Dis. 2007 Mar.

Abstract

Data on non-bacterial infections during allogeneic non-myeloablative hematopoietic stem cell transplantation (HSCT) are widely different. We evaluated data on 48 consecutive patients who received a conditioning regimen with fludarabine and cyclophosphamide (73%) or fludarabine and total body irradiation (27%) and then underwent allogeneic non-myeloablative HSCT. Cytomegalovirus (CMV) infection was common and occurred in 48% of patients; 3 patients developed CMV disease, and all survived. CMV reactivation was found to be common with both conditioning regimens in our patient population. Invasive aspergillosis occurred in 4 patients (8%) and 3 died. Other serious non-bacterial infections were uncommon. Review of the available literature on non-myeloablative HSCT suggests that the frequency and type of opportunistic infections vary considerably.

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