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. 2007 Mar 12;21(5):645-7.
doi: 10.1097/QAD.0b013e32803277c7.

HIV entry inhibition by the envelope 2 glycoprotein of GB virus C

Susan Jung  1 , Melanie Eichenmüller, Norbert Donhauser, Frank Neipel, Alfred M Engel, Georg Hess, Bernhard Fleckenstein, Heide Reil
Affiliations

HIV entry inhibition by the envelope 2 glycoprotein of GB virus C

Susan Jung et al. AIDS. .

Abstract

Epidemiological studies have revealed an association between GB virus C (GBV-C) long-term viraemia and ameliorated HIV disease progression. We have provided evidence that a single protein of GBV-C, the glycoprotein E2, interferes with early HIV replication steps of both X4- and R5-tropic HIV strains. Preincubation with anti-E2 antibody specifically abrogates the inhibitory effect. Results were confirmed by the in-vitro expression of GBV-C E1/E2 encoding RNA.

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