INO80 subfamily of chromatin remodeling complexes

Abstract

ATP-dependent chromatin remodeling complexes contain ATPases of the Swi/Snf superfamily and alter DNA accessibility of chromatin in an ATP-dependent manner. Recently characterized INO80 and SWR1 complexes belong to a subfamily of these chromatin remodelers and are characterized by a split ATPase domain in the core ATPase subunit and the presence of Rvb proteins. INO80 and SWR1 complexes are evolutionarily conserved from yeast to human and have been implicated in transcription regulation, as well as DNA repair. The individual components, assembly patterns, and molecular mechanisms of the INO80 class of chromatin remodeling complexes are discussed in this review.

Figure 1

Schematic model of subunit interactions of the INO80 and SWR1 complexes. A) INO80 subunits and their interactions. B) SWR1 subunits and their interactions. The known interactions between subunits and ATPases are shown by arrows, while the question marks indicate unknown interactions. Figure 1B is adapted from Wu et al. [64].