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. 2007 Apr 1;17(7):2091-5.
doi: 10.1016/j.bmcl.2006.11.070. Epub 2006 Dec 1.

Synthesis and anti-HIV-1 activities of novel podophyllotoxin derivatives

Shi-Wu Chen  1 , Yun-Hua Wang, Yan Jin, Xuan Tian, Yong-Tang Zheng, Du-Qiang Luo, Yong-Qiang Tu
Affiliations

Synthesis and anti-HIV-1 activities of novel podophyllotoxin derivatives

Shi-Wu Chen et al. Bioorg Med Chem Lett. .

Abstract

In order to explore the range of biological activities of the podophyllotoxin compound class, a novel series of derivatives of podophyllotoxin, which were conjugates containing stavudine and different structural podophyllotoxin analogues, were designed, synthesized, and evaluated for their anti-HIV-1 activities in vitro. Among these compounds, 19d and 19c showed the highest anti-HIV-1 activities with EC(50) values of 0.17 and 0.29 microM and TI values of 466.9 and 354.5, respectively.

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