Comment
doi: 10.1016/j.molcel.2007.02.001.
HuR-SIRT: the hairy world of posttranscriptional control
Affiliations
- PMID: 17317621
- DOI: 10.1016/j.molcel.2007.02.001
Item in Clipboard
Comment
HuR-SIRT: the hairy world of posttranscriptional control
Mol Cell.
.
Free article
Abstract
In this issue of Molecular Cell, demonstrate that the RNA binding protein HuR selectively up- or downregulates the stability of the SIRT1 mRNA (which encodes an important regulatory deacetylase) depending upon phosphorylation by Chk2.
Comment on
-
Phosphorylation of HuR by Chk2 regulates SIRT1 expression.Mol Cell. 2007 Feb 23;25(4):543-57. doi: 10.1016/j.molcel.2007.01.011. Mol Cell. 2007. PMID: 17317627 Free PMC article.
Similar articles
-
AsSIRTing the DNA damage response.Trends Cell Biol. 2008 Feb;18(2):77-83. doi: 10.1016/j.tcb.2007.11.007. Epub 2008 Jan 22. Trends Cell Biol. 2008. PMID: 18215521 Free PMC article. Review.
-
Phosphorylation of HuR by Chk2 regulates SIRT1 expression.Mol Cell. 2007 Feb 23;25(4):543-57. doi: 10.1016/j.molcel.2007.01.011. Mol Cell. 2007. PMID: 17317627 Free PMC article.
-
Regulation of Bcl-2 expression by HuR in HL60 leukemia cells and A431 carcinoma cells.Mol Cancer Res. 2009 Aug;7(8):1354-66. doi: 10.1158/1541-7786.MCR-08-0476. Epub 2009 Aug 11. Mol Cancer Res. 2009. PMID: 19671677
-
Signalling pathways regulating nucleo-cytoplasmic shuttling of the mRNA-binding protein HuR.Cell Signal. 2008 Dec;20(12):2165-73. doi: 10.1016/j.cellsig.2008.05.007. Epub 2008 May 23. Cell Signal. 2008. PMID: 18585896 Review.
-
HuR as a negative posttranscriptional modulator in inflammation.Mol Cell. 2005 Sep 16;19(6):777-89. doi: 10.1016/j.molcel.2005.08.007. Mol Cell. 2005. PMID: 16168373
Cited by
-
AsSIRTing the DNA damage response.Trends Cell Biol. 2008 Feb;18(2):77-83. doi: 10.1016/j.tcb.2007.11.007. Epub 2008 Jan 22. Trends Cell Biol. 2008. PMID: 18215521 Free PMC article. Review.
-
Cloning, expression, purification and preliminary crystallographic studies of the adenylate/uridylate-rich element-binding protein HuR complexed with its target RNA.Acta Crystallogr Sect F Struct Biol Cryst Commun. 2009 Mar 1;65(Pt 3):285-7. doi: 10.1107/S174430910900400X. Epub 2009 Feb 26. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2009. PMID: 19255485 Free PMC article.
-
Sexual Dimorphism in Brain Sirtuin-1 and m6A Methylated Sirtuin-1 mRNA, and in Protection with Post-Injury Anti-miR-200c treatment, after Experimental Stroke in Aged Mice.Aging Dis. 2023 Jun 1;14(3):892-903. doi: 10.14336/AD.2022.1225. Aging Dis. 2023. PMID: 37191419 Free PMC article.
-
LncRNA mediated regulation of aging pathways in Drosophila melanogaster during dietary restriction.Aging (Albany NY). 2016 Sep 27;8(9):2182-2203. doi: 10.18632/aging.101062. Aging (Albany NY). 2016. PMID: 27687893 Free PMC article.
-
Connections between 3' end processing and DNA damage response: Ten years later.Wiley Interdiscip Rev RNA. 2020 Mar;11(2):e1571. doi: 10.1002/wrna.1571. Epub 2019 Oct 28. Wiley Interdiscip Rev RNA. 2020. PMID: 31657151 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Miscellaneous
