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Comment
. 2007 Feb 23;25(4):485-7.
doi: 10.1016/j.molcel.2007.02.001.

HuR-SIRT: the hairy world of posttranscriptional control

Carol J Wilusz  1 , Jeffrey Wilusz
Affiliations
Free article
Comment

HuR-SIRT: the hairy world of posttranscriptional control

Carol J Wilusz et al. Mol Cell. .
Free article

Abstract

In this issue of Molecular Cell, demonstrate that the RNA binding protein HuR selectively up- or downregulates the stability of the SIRT1 mRNA (which encodes an important regulatory deacetylase) depending upon phosphorylation by Chk2.

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  • Phosphorylation of HuR by Chk2 regulates SIRT1 expression.
    Abdelmohsen K, Pullmann R Jr, Lal A, Kim HH, Galban S, Yang X, Blethrow JD, Walker M, Shubert J, Gillespie DA, Furneaux H, Gorospe M. Abdelmohsen K, et al. Mol Cell. 2007 Feb 23;25(4):543-57. doi: 10.1016/j.molcel.2007.01.011. Mol Cell. 2007. PMID: 17317627 Free PMC article.

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