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. 2007;22(2):99-105.
doi: 10.1007/s10654-006-9103-0. Epub 2007 Feb 21.

Heritabilities, apolipoprotein E, and effects of inbreeding on plasma lipids in a genetically isolated population: the Erasmus Rucphen Family Study

Aaron Isaacs  1 , Fakhredin A Sayed-Tabatabaei, Yurii S Aulchenko, M Carola Zillikens, Eric J G Sijbrands, Anna F C Schut, Wim P F Rutten, Huibert A P Pols, Jacqueline C M Witteman, Ben A Oostra, Cornelia M van Duijn
Affiliations

Heritabilities, apolipoprotein E, and effects of inbreeding on plasma lipids in a genetically isolated population: the Erasmus Rucphen Family Study

Aaron Isaacs et al. Eur J Epidemiol. 2007.

Abstract

Despite considerable progress in unravelling the genetic basis of dyslipidemias, most findings are based on families with extreme phenotypes. We studied lipid levels in an extended pedigree ascertained irrespective of phenotype from the population of a recent genetic isolate in the Netherlands. Heritabilities of plasma lipid measures were examined; this analysis also included estimates of the proportion of variance attributable to ApoE genotype. The association between inbreeding and lipids was also considered, as a substantial fraction of the population had known inbreeding. A total of 868 individuals from this pedigree, containing more than 60,000 people over 15 generations, were investigated in this study. Laboratory analysis of these subjects included the determination of fasting plasma lipids. ApoE epsilon2/3/4 status was ascertained using TaqMan assays. Heritabilities for plasma lipids were estimated with adjustments for multiple covariates using SOLAR. Heritabilities for total cholesterol (TC), high-density lipoprotein cholesterol (HDL), low-density lipoprotein cholesterol (LDL), triglycerides (TG), TC/HDL ratio, and TG/HDL ratio were found to be 0.35, 0.56, 0.30, 0.24, 0.49, and 0.39, respectively. The addition of ApoE genotype in the model significantly decreased these estimates (Deltah(2) = -0.030, -0.004, -0.054, and -0.006 for TC, HDL, LDL, and TG). In a further analysis, TC and LDL were positively associated with the extent of inbreeding (p (trend) = 0.02 and p (trend) = 0.05, respectively). These data provide estimates of lipid heritability unbiased due to selection and suggest that this population represents a good opportunity to localize novel genes influencing plasma lipid levels.

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Figures

Figure 1
Figure 1
Plasma Lipid Means (95% CI) By Inbreeding Quartiles: All outcomes adjusted for age, sex, smoking, alcohol use, age*sex, age2, diabetes mellitus status, hormone replacement therapy, and lipid lowering therapy. * Significantly different from zero inbreeding. † Significantly different from first quartile. ‡ Significantly different from second quartile. ap for trend = 0.02, bp for trend = 0.05, cp for trend = 0.41, dp for trend = 0.69.
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References

    1. {'text': '', 'ref_index': 1, 'ids': [{'type': 'DOI', 'value': '10.1016/S0140-6736(06)68770-9', 'is_inner': False, 'url': 'https://doi.org/10.1016/s0140-6736(06)68770-9'}, {'type': 'PubMed', 'value': '16731270', 'is_inner': True, 'url': 'https://pubmed.ncbi.nlm.nih.gov/16731270/'}]}
    2. Lopez AD, Mathers CD, Ezzati M, Jamison DT, Murray CJ (2006) Global and regional burden of disease and risk factors, 2001: systematic analysis of population health data. Lancet 367:1747–757 - PubMed
    1. Executive Summary of The Third Report of The National Cholesterol Education Program (NCEP) (2001) Expert Panel on Detection, Evaluation, And Treatment of High Blood Cholesterol In Adults (Adult Treatment Panel III). Jama 285: 2486–497 - PubMed
    1. {'text': '', 'ref_index': 1, 'ids': [{'type': 'DOI', 'value': '10.1016/j.amjmed.2004.02.005', 'is_inner': False, 'url': 'https://doi.org/10.1016/j.amjmed.2004.02.005'}, {'type': 'PubMed', 'value': '15050186', 'is_inner': True, 'url': 'https://pubmed.ncbi.nlm.nih.gov/15050186/'}]}
    2. LaRosa JC, Gotto AM Jr. (2004) Past, present, and future standards for management of dyslipidemia. Am J Med 116(Suppl 6A):3S–S - PubMed
    1. {'text': '', 'ref_index': 1, 'ids': [{'type': 'DOI', 'value': '10.1016/S0021-9150(00)00603-1', 'is_inner': False, 'url': 'https://doi.org/10.1016/s0021-9150(00)00603-1'}, {'type': 'PubMed', 'value': '11164415', 'is_inner': True, 'url': 'https://pubmed.ncbi.nlm.nih.gov/11164415/'}]}
    2. Despres JP, Lemieux I, Dagenais GR, Cantin B, Lamarche B (2000) HDL-cholesterol as a marker of coronary heart disease risk: the Quebec cardiovascular study. Atherosclerosis 153:263–72 - PubMed
    1. {'text': '', 'ref_index': 1, 'ids': [{'type': 'DOI', 'value': '10.1086/320112', 'is_inner': False, 'url': 'https://doi.org/10.1086/320112'}, {'type': 'PMC', 'value': 'PMC1226113', 'is_inner': False, 'url': 'https://pmc.ncbi.nlm.nih.gov/articles/PMC1226113/'}, {'type': 'PubMed', 'value': '11309690', 'is_inner': True, 'url': 'https://pubmed.ncbi.nlm.nih.gov/11309690/'}]}
    2. Abney M, McPeek MS, Ober C (2001) Broad and narrow heritabilities of quantitative traits in a founder population. Am J Hum Genet 68:1302–307 - PMC - PubMed

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