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Review
. 2007 Feb;39(1):79-84.
doi: 10.1007/s10863-006-9063-9.

Galectin-3 in apoptosis, a novel therapeutic target

Pratima Nangia-Makker  1 , Susumu Nakahara, Victor Hogan, Avraham Raz
Affiliations
Review

Galectin-3 in apoptosis, a novel therapeutic target

Pratima Nangia-Makker et al. J Bioenerg Biomembr. 2007 Feb.

Abstract

During the past decade, extensive progress has been made toward understanding the molecular basis for the regulation of apoptosis. In mammalian cells undergoing apoptosis, two distinct mechanisms or pathways are operated and are triggered by cell death stimuli from intra- or extra-cellular environments, namely the intrinsic or extrinsic pathways, resulting in mitochondrial membrane depolarization. Several lines of evidence from our laboratories and others have indicated that galectin-3 plays an important role in these pathways by binding to various ligands. Here the authors provide a brief discussion on the role of endogenous or extra-cellular galectin-3 in the regulation of apoptosis and how it could be used as a therapeutic target using natural plant products as its functional inhibitors.

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Figures

Fig. 1
Fig. 1
A model for the regulation of extrinsic and intrinsic apoptotic pathways by galectin-3
See this image and copyright information in PMC

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