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. 1992 Jan 28;31(3):654-61.
doi: 10.1021/bi00118a004.

Solution structure of the lipophosphoglycan of Leishmania donovani

S W Homans  1 , A Mehlert, S J Turco
Affiliations

Solution structure of the lipophosphoglycan of Leishmania donovani

S W Homans et al. Biochemistry. .

Abstract

The three-dimensional solution structure of the repeating -PO4-6Gal beta 1-4Man alpha 1- disaccharide fragment of the lipophosphoglycan (LPG) derived from Leishmania donovani has been determined by use of a combination of homo- and heteronuclear NMR spin coupling constant measurements together with restrained molecular mechanical minimization and molecular dynamics simulations. The fragment exists with limited mobility in solution about the Gal beta 1-4Man linkages, whereas in contrast a variety of stable rotamers exist about the Man alpha 1-PO4-6Gal linkages. These rotamers define several major stable conformers in solution, which are discussed in terms of the proposed biological role of LPG.

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