Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2007 Mar;91(2):199-211.
doi: 10.1016/j.mcna.2006.10.003.

Opioid tolerance and hyperalgesia

Grace Chang  1 , Lucy Chen, Jianren Mao
Affiliations
Review

Opioid tolerance and hyperalgesia

Grace Chang et al. Med Clin North Am. 2007 Mar.

Abstract

Opioids have been successfully used for the management of acute and cancer-related pain. Concerns regarding side effects, tolerance, dependence, addiction, and hyperalgesia have limited the use of opioids for the management of chronic nonmalignant pain. This article will review updated information from both clinical and preclinical studies regarding opioid-induced hyperalgesia, tolerance, and dependence. The implications of these issues in clinical opioid therapy also will be discussed.

PubMed Disclaimer

Substances