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Clinical Trial
. 2007 Feb 27;68(9):688-90.
doi: 10.1212/01.wnl.0000255937.27012.ee.

Safety and feasibility of long-term temozolomide treatment in patients with high-grade glioma

P Hau  1 , D Koch, T Hundsberger, E Marg, B Bauer, R Rudolph, M Rauch, A Brenner, P Rieckmann, J Schuth, T Jauch, H Koch, U Bogdahn
Affiliations
Clinical Trial

Safety and feasibility of long-term temozolomide treatment in patients with high-grade glioma

P Hau et al. Neurology. .

Abstract

We surveyed neuro-oncologists regarding patients treated with temozolomide for at least 12 cycles or 12 months. Patients receiving first-line temozolomide for a median 13 cycles had a median progression-free survival (PFS) of 14 months. Patients with recurrent disease receiving a median 14 cycles had a median PFS of 15.5 months. A small percentage of patients experienced grade III to IV toxicity. These results suggest that long-term treatment with temozolomide is feasible and well tolerated.

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