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Comparative Study
. 2007 Feb;78(2):139-43.
doi: 10.1111/j.1600-0609.2006.00780.x.

Abnormality of CD4(+)CD25(+) regulatory T cells in idiopathic thrombocytopenic purpura

Bin Liu  1 , Hui Zhao, Man-Chiu Poon, Zhibo Han, Dongsheng Gu, Maoqiang Xu, Hairong Jia, Renchi Yang, Zhong Chao Han
Affiliations
Comparative Study

Abnormality of CD4(+)CD25(+) regulatory T cells in idiopathic thrombocytopenic purpura

Bin Liu et al. Eur J Haematol. 2007 Feb.

Abstract

Objectives: The aim of this study was to explore the profile and function of CD4(+)CD25(+) regulatory T cells (Treg cells) in idiopathic thrombocytopenic purpura (ITP) patients.

Methods: Treg cell numbers were analyzed by flow cytometric analysis in peripheral blood mononuclear cells collected from healthy donors or patients with ITP. Quantification of cell proliferation was assayed by an enzyme-linked immunosorbent assay kit, based on the measurement of BrdU incorporation during DNA synthesis.

Results: The percentage of Treg cells was significantly decreased in ITP patients in active and non-remission state(5.79 +/- 1.22%) when compared with the patients in remission(11.63 +/- 4.56%) and to healthy subjects(12.68 +/- 3.59%). The suppressive activity of Treg cells in ITP patients was also found to be impaired.

Conclusion: These results suggest that decreased number and function of Treg cells might be one of mechanisms that cause immune regulation dysfunction in ITP.

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