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Randomized Controlled Trial
. 2007 Sep;92(5):F367-71.
doi: 10.1136/adc.2006.098566. Epub 2007 Feb 28.

Dopamine versus dobutamine in very low birthweight infants: endocrine effects

Luca Filippi  1 , Marco Pezzati, Chiara Poggi, Sauro Rossi, Alessandra Cecchi, Cristina Santoro
Affiliations
Randomized Controlled Trial

Dopamine versus dobutamine in very low birthweight infants: endocrine effects

Luca Filippi et al. Arch Dis Child Fetal Neonatal Ed. 2007 Sep.

Abstract

Objectives: To compare the endocrine effects of dopamine and dobutamine in hypotensive very low birthweight (VLBW) infants.

Design: Non-blinded randomised prospective trial.

Setting: Level III neonatal intensive care unit.

Patients: 35 hypotensive VLBW infants who did not respond to volume loading, assigned to receive dopamine or dobutamine.

Measurements: Haemodynamic variables and serum levels of thyroid stimulating hormone (TSH), total thyroxine (T(4)), prolactin (PRL) and growth hormone were assessed during the first 72 h of treatment and the first 72 h after stopping treatment.

Results: Demographic and clinical data did not significantly differ between the two groups. Necessary cumulative and mean drug doses and maximum infusion required to normalise blood pressure were significantly higher in the dobutamine than in the dopamine group (p<0.01). Suppression of TSH, T(4) and PRL was observed in dopamine-treated newborns from 12 h of treatment onwards, whereas levels of growth hormone reduced significantly only at 12 h and 36 h of treatment (p<0.01). TSH, T(4) and PRL rebound was observed from the first day onwards after stopping dopamine. Dobutamine administration did not alter the profile of any of the hormones and no rebound was observed after stopping treatment.

Conclusion: Dopamine and dobutamine both increase the systemic blood pressure, though dopamine is more effective. Dopamine reduces serum levels of TSH, T(4) and PRL in VLBW infants but such suppression is quickly reversed after treatment is stopped. Further research is required to assess if short-term iatrogenic pituitary suppression has longer-term consequences.

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Conflict of interest statement

Competing interests: None.

References

    1. Gill A B, Weindling A M. Randomised controlled trial of plasma protein fraction versus dopamine in hypotensive very low birthweight infants. Arch Dis Child 199369284–287. - PMC - PubMed
    1. Cunningham S, Symon A G, Elton R A.et al Intra‐arterial blood pressure reference ranges, death and morbidity in very low birthweight infants during the first seven days of life. Early Hum Dev 199956151–165. - PubMed
    1. Goldstein R F, Thompson R J, Oehler J M.et al Influence of acidosis, hypoxaemia, and hypotension on neurodevelopmental outcome in very low birth weight infants. Pediatrics 199595238–243. - PubMed
    1. Miall‐Allen V M, De Vries L S, Whitelaw A G L. Mean arterial blood pressure and neonatal cerebral lesions. Arch Dis Child 1987621068–1069. - PMC - PubMed
    1. Munro M J, Walker A M, Barfield C P. Hypotensive extremely low birth weight infants have reduced cerebral blood flow. Pediatrics 20041141591–1596. - PubMed

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