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Comment
. 2007 Mar;9(3):247-9.
doi: 10.1038/ncb0307-247.

Untangling the signalling wires

Boris N Kholodenko
Comment

Untangling the signalling wires

Boris N Kholodenko. Nat Cell Biol. 2007 Mar.

Abstract

Mitogen-activated protein kinase (MAPK) cascades process myriads of stimuli, generating receptor-specific cellular outcomes. New work exploits emergent mathematics of network inference to reveal distinct feedback designs of the RAF/MEK/ERK cascade induced by two different growth factors. It shows that response specificity can arise from differential signal-induced wiring of overlapping protein networks.

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Figures

Fig. 1
Fig. 1. Quantification and unravelling of network connections
Applying four independent perturbations (shown by lightning bolts) to the network of four nodes, the global response coefficients Rkj are measured. From these data, connection coefficients rij are calculated,.
See this image and copyright information in PMC

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References

    1. Marshall CJ. Cell. 1995;80:179–85. - PubMed
    1. Murphy LO, MacKeigan JP, Blenis J. Mol Cell Biol. 2004;24:144–53. - PMC - PubMed
    1. Kao S, Jaiswal RK, Kolch W, Landreth GE. J Biol Chem. 2001;276:18169–77. - PubMed
    1. Sasagawa S, Ozaki Y, Fujita K, Kuroda S. Nat Cell Biol. 2005;7:365–73. - PubMed
    1. Santos SDM, Verveer P, Bastiaens PIH. Nature Cell Biol. 2007 - PubMed

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