Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1992 Jan;53(1):136-9.
doi: 10.1097/00007890-199201000-00027.

Disease recurrence and rejection following liver transplantation for autoimmune chronic active liver disease

H L Wright  1 , C F Bou-Abboud, T Hassanein, G D Block, A J Demetris, T E Starzl, D H Van Thiel
Affiliations

Disease recurrence and rejection following liver transplantation for autoimmune chronic active liver disease

H L Wright et al. Transplantation. 1992 Jan.

Abstract

Autoimmune chronic active liver disease (ACALD), a major indication for liver transplantation, is associated strongly with antigenic determinants HLA-B8 and DR3. A retrospective analysis of 43 patients who underwent OLTx for putative ACALD and who, as well as their tissue organ donors, were typed, was performed. Disease recurrence and graft rejection episodes were determined by chart review and histopathological review of all material available. Disease recurrence was histologically documented in 11 (25.6%) of these 43 cases. Graft rejection episodes occurred in 24 (55.8%). All recurrences were in recipients of HLA-DR3-negative grafts. Nine of the recurrences were in HLA-DR3-positive recipients (odds ratio: 6.14, P less than 0.03). Two of 11 cases of disease recurrence were in recipients who were HLA-DR3-negative. Nine of these 11 had received HLA-DR3-negative grafts. Rejection occurred in 13 HLA-B8-positive recipients, 12 of whom received HLA-B8-negative grafts. Eleven HLA-B8-negative recipients experienced at least one rejection episode and 9 of these had received HLA-B8-negative grafts. Based upon these data we conclude: 1) that recurrence of putative ACALD is more likely to occur in HLA-DR3-positive recipients of HLA-DR3-negative grafts; (2) that recurrences were not seen in recipients of HLA-DR3-positive grafts; (3) that HLA-B8 status does not affect disease recurrence; and (4) that neither the HLA-B8 nor the DR3 status of the graft or recipient has an effect on the observed frequency of rejection.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Percentage of recipients experiencing disease recurrence based upon the HLA-DR3 status of the donor-recipient pairing.
Figure 2
Figure 2
Percentage of recipients experiencing disease recurrence based upon the HLA-B8 status of the donor-recipient pairing.
Figure 3
Figure 3
Percentage of recipients experiencing graft rejection based upon the HLA-DR3 status of the donor-recipient pairing.
Figure 4
Figure 4
Percentage of recipients experiencing graft rejection based upon the HLA-B8 status of the donor-recipient pairing.
See this image and copyright information in PMC

References

    1. Mackay RR, Morris PJ. Association of autoimmune chronic active hepatitis with HLA-A1, B8. Lancet. 1972;2:793. - PubMed
    1. MacKay IR, Tait BD. HLA associations with autoimmune-type chronic active hepatitis: identification of B8-DRw3 haplotype by family studies. Gastroenterology. 1980;79:95. - PubMed
    1. Neuberger J, Portmann B, Calne R, Williams R. Recurrence of autoimmune chronic active hepatitis following orthotopic liver grafting. Transplantation. 1984;37:363. - PubMed
    1. Gordon RD, Fung JJ, Markus B, et al. The antibody crossmatch in liver transplantation. Surgery. 1986;100:705. - PMC - PubMed
    1. Snover DC, Sibley RK, Freese DK, et al. Orthotopic liver transplantation: a pathological study of 63 serial liver biopsies from 17 patients with specific reference to the diagnostic features and natural history of rejection. Hepatology. 1984;4:1212. - PubMed