Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2008 Mar;50(3):660-2.
doi: 10.1002/pbc.21180.

CD36 immunization in a patient undergoing hematopoietic stem cell transplantation

Elizabeth E Culler  1 , Christopher D Hillyer, Ann E Haight, Marta-Inés Castillejo, Cassandra D Josephson
Affiliations
Case Reports

CD36 immunization in a patient undergoing hematopoietic stem cell transplantation

Elizabeth E Culler et al. Pediatr Blood Cancer. 2008 Mar.

Abstract

Anti-CD36 antibodies are known to cause a platelet refractory state. We describe a previously unreported case of a 16-year-old female sickle cell disease patient with anti-CD36 antibodies, detected on routine screen prior to hematopoietic stem cell transplantation (HSCT). CD36 platelet antigen typing was negative for both the patient and her HLA-identical donor sibling. Patient plasma was compatible with 48 of 49 apheresis platelets, which were untested and presumably positive for the CD36 antigen. The patient responded adequately to transfusion of crossmatch compatible platelets and successfully underwent HSCT. The presence of anti-CD36 antibodies does not exclude potential candidates from HSCT.

PubMed Disclaimer

Publication types