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. 2007 Apr;3(4):211-2.
doi: 10.1038/nchembio867. Epub 2007 Mar 4.

Discovery of a natural thiamine adenine nucleotide

Lucien Bettendorff  1 , Barbara Wirtzfeld, Alexander F Makarchikov, Gabriel Mazzucchelli, Michel Frédérich, Tiziana Gigliobianco, Marjorie Gangolf, Edwin De Pauw, Luc Angenot, Pierre Wins
Affiliations
Free article

Discovery of a natural thiamine adenine nucleotide

Lucien Bettendorff et al. Nat Chem Biol. 2007 Apr.
Free article

Abstract

Several important cofactors are adenine nucleotides with a vitamin as the catalytic moiety. Here, we report the discovery of the first adenine nucleotide containing vitamin B1: adenosine thiamine triphosphate (AThTP, 1), or thiaminylated ATP. We discovered AThTP in Escherichia coli and found that it accumulates specifically in response to carbon starvation, thereby acting as a signal rather than a cofactor. We detected smaller amounts in yeast and in plant and animal tissues.

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