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. 1992 Jan;65(1):87-9.
doi: 10.1038/bjc.1992.16.

Evaluation of bcl-2 protein expression and 14;18 translocation as prognostic markers in follicular lymphoma

F Pezzella  1 , M Jones, E Ralfkiaer, J Ersbøll, K C Gatter, D Y Mason
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Free PMC article

Evaluation of bcl-2 protein expression and 14;18 translocation as prognostic markers in follicular lymphoma

F Pezzella et al. Br J Cancer. 1992 Jan.
Free PMC article

Abstract

Conflicting results have been published on the prognostic significance of t(14;18) in follicular lymphoma: Yunis et al. (1989) reported that its presence indicated poor response to therapy and short survival, whereas Levine et al. (1988) showed no difference in prognosis between cases with and without the translocation. However these results were based on small series of cases and on follow-up periods (no longer than 7 years) which are relatively short for a disease with such a slow clinical evolution. Here we report an investigation of 70 cases of follicular lymphoma with long term follow-up data (up to 17 years). This series has been studied for the presence of the 14;18 translocation and for the expression of bcl-2 protein. Our results show that there are no grounds for considering either the 14;18 translocation or the expression of the bcl-2 protein to be useful prognostic markers in clinical practice.

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References

    1. Nature. 1991 Jul 25;352(6333):345-7 - PubMed
    1. Br J Haematol. 1990 Sep;76(1):58-64 - PubMed
    1. N Engl J Med. 1989 Apr 20;320(16):1047-54 - PubMed
    1. Ann Intern Med. 1988 Jan;108(1):14-20 - PubMed
    1. Nature. 1988 Sep 29;335(6189):440-2 - PubMed

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