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. 2007 Jul;16(7):977-82.
doi: 10.1007/s00586-007-0336-8. Epub 2007 Mar 3.

Modic changes following lumbar disc herniation

Hanne B Albert  1 , Claus Manniche
Affiliations

Modic changes following lumbar disc herniation

Hanne B Albert et al. Eur Spine J. 2007 Jul.

Abstract

Only a small proportion (20%) of patients with LBP can be diagnosed based on a patho-anatomical entity. Therefore, the identification of relevant subgroups, preferably on a patoanatomical basis, is strongly needed. Modic changes have been described by several authors as being closely linked with LBP. The aims of this study were to describe the prevalence of Modic changes, their development as well as their association to LBP, previous disc contour, and surgery in patients with previous severe sciatica. This is a longitudinal cohort study where the patients were recruited from an RCT comparing two active conservative treatments, the 181 patients, who at baseline had radicular pain in or below the knee; all underwent a physical examination and MRI. MRI's, pain history and physical examination of 166 patients were obtained at follow-up 14 months later. The prevalence of Modic changes type 1 increased from 9% at baseline to 29% at follow-up. At that time, a strong association between Modic changes and non-specific LBP was noted. Apparently, Modic changes type 1 was more strongly associated with non-specific lumbar pain than Modic changes type 2. The development of new Modic changes was closely related to the level of a previous disc herniation. A lumbar disc herniation is a strong risk factor for developing Modic changes (especially type 1) during the following year. Furthermore, Modic changes are strongly associated with LBP.

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Figures

Fig. 1
Fig. 1
Modic changes type 1 in lower endplate of the L4 vertebrae and the upper endplate of the L5 vertebrae
Fig. 2
Fig. 2
Modic changes type 2 in the lower endplate of the L5 vertebrae and the upper endplate of the S1
Fig. 3
Fig. 3
The prevalence of Modic changes type 1, 2 and 3 and patients with both type 1 and 2 at baseline (n = 180) and at 14 months follow-up (n = 166) in patients with originally severe sciatica
Fig. 4
Fig. 4
The total number of Modic changes in the upper and lower endplate for each lumbar vertebra, described both at baseline and at follow-up
Fig. 5
Fig. 5
The distribution of the different types of Modic changes in relation to lumbar pain (n = 166)
See this image and copyright information in PMC

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