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. 2007 Jun;12(5):631-5.
doi: 10.1007/s00775-007-0222-1. Epub 2007 Mar 3.

The interactions of cobalt(II) with mitochondria from rat liver

Marcantonio Bragadin  1 , Antonio Toninello, Mario Mancon, Sabrina Manente
Affiliations
Free article

The interactions of cobalt(II) with mitochondria from rat liver

Marcantonio Bragadin et al. J Biol Inorg Chem. 2007 Jun.
Free article

Abstract

The interactions of Co(2+) with mitochondria have been investigated. The results indicate that Co(2+) inhibits ATP synthesis. Further investigations into ATP synthesis mechanisms indicated that inhibition is due to the opening of a transmembrane pore. The opening of this pore causes the collapse of the high-energy intermediate where, under a pH and a potential gradient, the energy is stored and subsequently utilized to form ATP from ADP.

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