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. 2007 Dec;20(8):757-62.
doi: 10.1002/nbm.1141.

Glutamate measurement in Parkinson's disease using MRS at 3 T field strength

Nils Kickler  1 , Paul Krack, Valérie Fraix, Jean-François Lebas, Laurent Lamalle, Franck Durif, Alexandre Krainik, Chantal Rémy, Christoph Segebarth, Pierre Pollak
Affiliations

Glutamate measurement in Parkinson's disease using MRS at 3 T field strength

Nils Kickler et al. NMR Biomed. 2007 Dec.

Abstract

Loss of nigral dopamine neurons in Parkinson's disease induces abnormal activation of glutamate systems in the basal ganglia. The purpose of this study was to assess these changes in the lentiform nucleus using MRS with optimized glutamate sensitivity (TE-averaged method). Ten patients with Parkinson's disease and 10 healthy controls were examined. Compared with healthy controls, no significant differences in glutamate were measured in patients, but a trend to lower total creatine was observed.

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