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. 2007 Aug;855(1):66-70.
doi: 10.1016/j.jchromb.2007.02.028. Epub 2007 Feb 24.

Serum protein profile of rheumatoid arthritis treated with anti-TNF therapy (infliximab)

Tohru Takeuchi  1 , Toyofumi Nakanishi, Yoko Tabushi, Ayu Hata, Takeshi Shoda, Takuya Kotani, Akira Shimizu, Takayuki Takubo, Shigeki Makino, Toshiaki Hanafusa
Affiliations

Serum protein profile of rheumatoid arthritis treated with anti-TNF therapy (infliximab)

Tohru Takeuchi et al. J Chromatogr B Analyt Technol Biomed Life Sci. 2007 Aug.

Abstract

We analyzed the changes in the serum protein profile by infliximab using two-dimensional gel electrophoresis and mass spectrometry. More than 50 gel spots were seen to increase or decrease in correlation with clinical improvements of RA. The spots corresponding to CRP, C3, and Apo J showed reduced staining intensity, while the spots corresponding to Apo A-I, RBP, and transthyretin were enhanced. The protein profile of RA patients treated with infliximab was mostly similar to that of normal healthy controls except for several protein spots. This suggested that infliximab normalized the serum protein profile of RA patients, leading to modification in the serum lipid profile and antioxidant status in RA.

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