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Randomized Controlled Trial
. 2007 Jul;88(1):227-30.
doi: 10.1016/j.fertnstert.2006.11.071. Epub 2007 Mar 6.

Prospective, randomized trial of metformin and vitamins for the reduction of plasma homocysteine in insulin-resistant polycystic ovary syndrome

Morey Schachter  1 , Arieh Raziel, Devorah Strassburger, Carmela Rotem, Raphael Ron-El, Shevach Friedler
Affiliations
Free article
Randomized Controlled Trial

Prospective, randomized trial of metformin and vitamins for the reduction of plasma homocysteine in insulin-resistant polycystic ovary syndrome

Morey Schachter et al. Fertil Steril. 2007 Jul.
Free article

Abstract

One hundred and two women with insulin-resistant polycystic ovary syndrome were randomized to treatment with a vitamin B preparation, metformin, or both, in conjunction with standard infertility treatment. Plasma homocysteine levels were significantly reduced by both B vitamins and metformin, but to a greater degree by B vitamins, and higher pregnancy rates were associated with vitamin B treatment.

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