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Review
. 2007 Feb-Apr;18(1-2):97-105.
doi: 10.1016/j.cytogfr.2007.01.009. Epub 2007 Mar 6.

Cross-talk between apoptosis and cytokines in the regulation of parasitic infection

George A DosReis  1 , Flavia L Ribeiro-Gomes, Landi V C Guillermo, Marcela F Lopes
Affiliations
Review

Cross-talk between apoptosis and cytokines in the regulation of parasitic infection

George A DosReis et al. Cytokine Growth Factor Rev. 2007 Feb-Apr.

Abstract

Parasitic diseases have worldwide medical and economical impact. Host T lymphocytes and the cytokines they produce determine the outcome of parasitic infections. Programmed cell death by apoptosis is induced in the course of parasitic infections, and affects cytokine production by removing activated effector T and B cells. In addition, engulfment of apoptotic cells promotes the secretion of cytokines that regulate intracellular replication of protozoan parasites. In this review, we discuss how the cross-talk between apoptosis and cytokines regulates parasitic infection.

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