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Review
. 2006;36(1-3):147-55.
doi: 10.1385/IR:36:1:147.

Immune regulation by the TIM gene family

Anjali J de Souza  1 , Lawrence P Kane
Affiliations
Review

Immune regulation by the TIM gene family

Anjali J de Souza et al. Immunol Res. 2006.

Abstract

Recent studies have demonstrated that proteins of the T cell immunoglobulin and mucin domain (TIM) family are important regulators of immune function. Here we discuss the functional effects of TIM proteins on immune responses, how the effects of TIM proteins may be modulated by interactions with ligands and the limited information available on intracellular signals downstream of TIM proteins.

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