[Effect of cyclic nucleotides on the transformation and proliferation of lymphocytes]

Abstract

When the studies on the immunologic system have met with the "second messenger" hypothesis of the cyclic nucleotides, new ideas have arisen about mechanisms regulating the immunologic reactions. Several works sustain a specific action of cyclic AMP and cyclic GMP to modulate the immunologic system, but the more subtle actions must be discovered. A hypothesis which attributes the control-task of the cellular functions to the c-AMP/c-GMP relation is presented.