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Comment
. 2007 Mar;5(3):161-3.
doi: 10.1016/j.cmet.2007.02.005.

The path to insulin resistance: paved with ceramides?

Juleen R Zierath  1
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Free article
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The path to insulin resistance: paved with ceramides?

Juleen R Zierath. Cell Metab. 2007 Mar.
Free article

Abstract

Obesity-associated, system-wide elevations in free fatty acids, tumor necrosis factor alpha, and glucocorticoids increase intracellular lipid metabolites and promote insulin resistance. In this issue, Holland et al. (2007) provide pharmacological and genetic evidence that ceramide plays a key role in the development of insulin resistance induced by these factors.

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