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Review
. 2007 Mar;83(977):148-51.
doi: 10.1136/pgmj.2006.049734.

Heights and haematology: the story of haemoglobin at altitude

Jeremy S Windsor  1 , George W Rodway
Affiliations
Review

Heights and haematology: the story of haemoglobin at altitude

Jeremy S Windsor et al. Postgrad Med J. 2007 Mar.

Abstract

In order to compensate for the low partial pressure of oxygen at altitude, the human body undergoes a number of physiological changes. A vital component in this process is the increase in the concentration of circulating haemoglobin. The role of HIF-1alpha, erythropoietin and red blood cells in this acclimatisation process is described, together with the fall in plasma volume that increases the concentration of haemoglobin in the early stages of hypoxic exposure.

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Conflict of interest statement

Competing interests: None.

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