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. 1992 Jan 31;182(2):644-50.
doi: 10.1016/0006-291x(92)91781-k.

Effect of extracellular phosphatidylinositol on c-myc gene-expressed human renal cancer cell line

S Noguchi  1 , Y Kubota, T Shuin, E Ito, H Inoue, T Yoshioka
Affiliations

Effect of extracellular phosphatidylinositol on c-myc gene-expressed human renal cancer cell line

S Noguchi et al. Biochem Biophys Res Commun. .

Abstract

Effect of exogenously added soybean phosphatidylinositol on c-myc gene expressed and unexpressed human cancer cell lines was investigated. When phosphatidylinositol liposomes were introduced into culture media, viability of c-myc unexpressed cells was reduced, while that of c-myc expressed cells was not. Death of c-myc unexpressed cells by phosphatidylinositol liposomes was found to be caused by abnormally accumulated intracellular Ca2+, and it seemed to be related to reduction of protein kinase C activity.

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