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Review
. 2007 Mar;7(2):189-208.
doi: 10.2174/187152007780058650.

Recent progress in discovery and development of antimitotic agents

Alex Kiselyov  1 , Konstantin V Balakin, Sergey E Tkachenko, Nikolay Savchuk, Alexandre V Ivachtchenko
Affiliations
Review

Recent progress in discovery and development of antimitotic agents

Alex Kiselyov et al. Anticancer Agents Med Chem. 2007 Mar.

Abstract

This review highlights structural diversity of antimitotic agents. In particular, we emphasized current antimitotic therapies based on modulation of microtubule dynamics. With several successful anticancer drugs on the market and numerous compounds in clinical developments, tubulin-binding agents remain among the most important categories of anticancer agents. Compounds targeting mitotic kinases and kinesins are also discussed.

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