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. 2007 Apr;78(3):192-5.
doi: 10.1016/j.fitote.2006.11.020. Epub 2007 Feb 7.

Antinociceptive effect and acute toxicity of the essential oil of Hyptis fruticosa in mice

Igor A C Menezes  1 , Maxsuel S Marques, Thiago C Santos, Kellyane S Dias, Aline B L Silva, Iderjane C M Mello, Ana C C D Lisboa, Péricles B Alves, Sócrates C H Cavalcanti, Rosilene M Marçal, Angelo R Antoniolli
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Antinociceptive effect and acute toxicity of the essential oil of Hyptis fruticosa in mice

Igor A C Menezes et al. Fitoterapia. 2007 Apr.

Abstract

The essential oil of the Hyptis fruticosa leaves was analyzed by GC/MS and evaluated for antinociceptive property as well as acute toxicity in mice. The essential oil, at doses of 100, 200, and 400 mg/kg (s.c.), produced significant inhibition of acetic acid-induced writhing, but did not manifest a significant effect in hot-plate test. There was no acute toxicity at doses up to 5 g/kg. Bicyclogermacrene, 1,8-cineole, alpha-pinene, and beta-caryophyllene were the major compounds detected in the essential oil.

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