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. 2007 Mar 9;128(5):823-4.
doi: 10.1016/j.cell.2007.02.020.

Magic spots cast a spell on DNA primase

Richard L Gourse  1 , James L Keck
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Magic spots cast a spell on DNA primase

Richard L Gourse et al. Cell. .
Free article

Abstract

The bacterial signaling molecules ppGpp and pppGpp regulate transcription initiation in response to starvation by altering RNA polymerase activity. In this issue, Wang et al. (2007) show that (p)ppGpp also inhibits DNA replication elongation by interfering with DNA primase activity. Halting replication may help cells to maintain genomic integrity during periods of transient nutrient limitation.

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