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. 2007 Apr;14(4):341-3.
doi: 10.1038/nsmb1216. Epub 2007 Mar 11.

The trithorax-group protein Lid is a histone H3 trimethyl-Lys4 demethylase

Nara Lee  1 , Junyu Zhang, Robert J Klose, Hediye Erdjument-Bromage, Paul Tempst, Richard S Jones, Yi Zhang
Affiliations

The trithorax-group protein Lid is a histone H3 trimethyl-Lys4 demethylase

Nara Lee et al. Nat Struct Mol Biol. 2007 Apr.

Abstract

Recent studies have demonstrated that histone methylation can be dynamically regulated through active demethylation. However, no demethylase specific to histone H3 trimethyl-Lys4 (H3K4me3) has been identified. Here we report that the Drosophila melanogaster protein 'little imaginal discs' (Lid), a JmjC domain-containing trithorax group protein, can demethylate H3K4me3. Consistent with its genetic classification, Lid positively regulates Hox gene expression in S2 cells.

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