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. 2007 Feb;27(2):150-2.

[MMP-2/TIMP-2 expression in the trophoblasts of patients with gestational trophoblastic disease]

[Article in Chinese]
Affiliations
  • PMID: 17355922

[MMP-2/TIMP-2 expression in the trophoblasts of patients with gestational trophoblastic disease]

[Article in Chinese]
Feng Ding et al. Nan Fang Yi Ke Da Xue Xue Bao. 2007 Feb.

Abstract

Objective: To explore the role of matrix metalloproteinase-2 (MMP-2) and tissue inhibitor of MMP-2 (TIMP-2) in the pathogenesis, development and prognosis of gestational trophoblastic disease (GTD).

Methods: In situ hybridization and immunohistochemistry were utilized for MMP-2/TIMP-2 mRNA and protein detection in normal chorion of women with early gestation, hydatidiform mole, invasive mole, or choricarcinoma.

Results: The results revealed that specific staining for mRNA and protein of MMP-2 and the expression of TIMP-2 was reduced in normal chorion of early gestation. In GTD ranging from hydatidiform mole, invasive mole to choricarcinoma, MMP-2 expression tended to increase while TIMP-2 expression underwent an invert change. The positivity rate of MMP-2 and TIMP-2 in gestational trophoblastic tumor group was higher than that of the normal chorion of early gestation group and hydatiform mole group (P<0.05 and P<0.001, respectively).

Conclusion: A disrupted balance between the activation and inhibition of MMP-2 plays a critical role in the pathogenesis, progression and metastasis of GTD.

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