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Comparative Study
. 2007 Apr 15;195(8):1177-80.
doi: 10.1086/512682. Epub 2007 Mar 2.

HIV-1 subtype D infection is associated with faster disease progression than subtype A in spite of similar plasma HIV-1 loads

Jared M Baeten  1 , Bhavna Chohan, Ludo Lavreys, Vrasha Chohan, R Scott McClelland, Laura Certain, Kishorchandra Mandaliya, Walter Jaoko, Julie Overbaugh
Affiliations
Comparative Study

HIV-1 subtype D infection is associated with faster disease progression than subtype A in spite of similar plasma HIV-1 loads

Jared M Baeten et al. J Infect Dis. .

Abstract

We investigated the effect of human immunodeficiency virus type 1 (HIV-1) subtype on disease progression among 145 Kenyan women followed from the time of HIV-1 acquisition. Compared with those infected with subtype A, women infected with subtype D had higher mortality (hazard ratio, 2.3 [95% confidence interval, 1.0-5.6]) and a faster rate of CD4 cell count decline (P=.003). The mortality risk persisted after adjustment for plasma HIV-1 load. There were no differences in plasma viral load by HIV-1 subtype during follow-up. HIV-1 subtype D infection is associated with a >2-fold higher risk of death than subtype A infection, in spite of similar plasma HIV-1 loads.

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