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Clinical Trial
. 2007 Apr 15;195(8):1181-3.
doi: 10.1086/512679. Epub 2007 Mar 2.

Treatment of chronic hepatitis B or C in HIV-infected patients with dual viral hepatitis

Vincent Soriano  1 , Pablo Barreiro, Luz Martín-Carbonero, Carol Castellares, Andres Ruiz-Sancho, Pablo Labarga, Belen Ramos, Juan Gonzalez-Lahoz
Affiliations
Clinical Trial

Treatment of chronic hepatitis B or C in HIV-infected patients with dual viral hepatitis

Vincent Soriano et al. J Infect Dis. .

Abstract

Dual chronic hepatitis B virus (HBV) and hepatitis C virus (HCV) infections are recognized in 3%-5% of human immunodeficiency virus (HIV)-infected individuals. More severe liver disease is seen in these patients. Viral interference may account for the fact that replication of one virus generally predominates over replication of the other. The impact that treatment of HBV or HCV infection has on this reciprocal inhibition is not well established. No evidence of reactivation of either HBV or HCV was seen when complete suppression of the other predominant virus was achieved with specific therapy in 21 subjects with HIV infection and dual HBV/HCV infections. This information has important pathogenic implications and may influence therapeutic decisions.

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