Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2007 Mar 2;98(9):098105.
doi: 10.1103/PhysRevLett.98.098105. Epub 2007 Feb 27.

How Xenopus laevis replicates DNA reliably even though its origins of replication are located and initiated stochastically

John Bechhoefer  1 , Brandon Marshall
Affiliations

How Xenopus laevis replicates DNA reliably even though its origins of replication are located and initiated stochastically

John Bechhoefer et al. Phys Rev Lett. .

Abstract

DNA replication in Xenopus laevis is extremely reliable, failing to complete before cell division no more than once in 10 000 times; yet replication origin sites are located and initiated stochastically. Using a model based on 1D theories of nucleation and growth and using concepts from extreme-value statistics, we derive the distribution of replication times given a particular initiation function. We show that the experimentally observed initiation strategy for Xenopus laevis meets the reliability constraint and is close to the one that requires the fewest resources of a cell.

PubMed Disclaimer

Publication types