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Review
. 2007 May;6(1):28-45.
doi: 10.1016/j.arr.2007.02.005. Epub 2007 Feb 20.

Hormonal regulation of longevity in mammals

Holly M Brown-Borg  1
Affiliations
Review

Hormonal regulation of longevity in mammals

Holly M Brown-Borg. Ageing Res Rev. 2007 May.

Abstract

Multiple biological and environmental factors impact the life span of an organism. The endocrine system is a highly integrated physiological system in mammals that regulates metabolism, growth, reproduction, and response to stress, among other functions. As such, this pervasive entity has a major influence on aging and longevity. The growth hormone, insulin-like growth factor-1 and insulin pathways have been at the forefront of hormonal control of aging research in the last few years. Other hormones, including those from the thyroid and reproductive system have also been studied in terms of life span regulation. The relevance of these hormones to human longevity remains to be established, however the evidence from other species including yeast, nematodes, and flies suggest that evolutionarily well-conserved mechanisms are at play and the endocrine system is a key determinant.

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References

    1. Allolio B, Arlt W. DHEA treatment: myth or reality? Trends Endocrinol Metab. 2002;13:288–294. - PubMed
    1. Aragno M, Brignardello E, Tamagno E, Gatto V, Danni O, Boccuzzi G. Dehydroepiandrosterone administration prevents the oxidative damage induced by acute hyperglycemia in rats. J Endocrinol. 1997;155:233–240. - PubMed
    1. Aragno M, Tamagno E, Boccuzzi G, Brignardello E, Chiarpotto E, Pizzini A, Danni O. Dehydroepiandrosterone pretreatment protects rats against the pro- oxidant and necrogenic effects of carbon tetrachloride. Biochem Pharmacol. 1993;46:1689–1694. - PubMed
    1. Aragno M, Tamagno E, Poli G, Boccuzzi G, Brignardello E, Danni O. Prevention of carbon tetrachloride-induced lipid peroxidation in liver microsomes from dehydroepiandrosterone-pretreated rats. Free Radic. Res. 1994;21:427–435. - PubMed
    1. Arlt W, Callies F, van Vlijmen JC, Koehler I, Reincke M, Bidlingmaier M, Huebler D, Oettel M, Ernst M, Schulte HM, Allolio B. Dehydroepiandrosterone replacement in women with adrenal insufficiency. N. Engl. J. Med. 1999;341:1013–1020. - PubMed

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