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Comment
. 2007 Mar 20;104(12):4777-8.
doi: 10.1073/pnas.0700913104. Epub 2007 Mar 12.

New tools to build synthetic hormonal pathways

Bruce R Conklin  1
Affiliations
Comment

New tools to build synthetic hormonal pathways

Bruce R Conklin. Proc Natl Acad Sci U S A. .
No abstract available

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Conflict of interest statement

The author declares no conflict of interest.

Figures

Fig. 1.
Fig. 1.
Construction of a designer receptor. Native hM3 receptor responds to the natural hormone (Ach) but does not respond to CNO (Upper). This receptor is matured through saturation mutagenesis to result in a designer receptor (Lower), which responds only to the designer drug (CNO) and is impervious to the natural hormone.
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