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. 2007 Apr 13;72(8):3133-6.
doi: 10.1021/jo062532p. Epub 2007 Mar 16.

General strategy for the construction of enantiopure pyrrolidine-based alkaloids. Total synthesis of (-)-monomorine

Suhong Zhang  1 , Liang Xu, Lei Miao, Hong Shu, Mark L Trudell
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General strategy for the construction of enantiopure pyrrolidine-based alkaloids. Total synthesis of (-)-monomorine

Suhong Zhang et al. J Org Chem. .

Abstract

An enantiopure cis-2,5-disubstituted pyrrolidine building block was prepared from cocaine. The synthetic utility of this compound as a chiral building block was demonstrated by a short and efficient synthesis of the pyrrolidine-based alkaloid (-)-monomorine (six steps, 37% overall yield).

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