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Review
. 2007 Mar;9(1):73-80.
doi: 10.1007/s11906-007-0013-7.

COX-2 and the vasculature: angel or evil?

Chiara Cuccurullo  1 , Andrea Mezzetti, Francesco Cipollone
Affiliations
Review

COX-2 and the vasculature: angel or evil?

Chiara Cuccurullo et al. Curr Hypertens Rep. 2007 Mar.

Abstract

Cyclooxygenase-2 (COX-2) may modulate atherosclerotic plaque stability or instability according to the prostaglandin synthase coupled with it. Whereas upregulation of COX-2 and prostaglandin (PG) E synthase is associated with plaque instability, overexpression of COX-2 and lipocalin-type PGD synthase leads to plaque stability. Thus, the role of COX-2 in atherothrombosis appears to be quite complex. In this article we summarize our recent papers investigating mechanisms regulating the expression and pharmacologic modulation of COX-2 in atherosclerotic plaques.

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