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Review
. 2007 Mar;30(1):13-29.
doi: 10.1016/j.psc.2007.01.001.

A critical overview of the pharmacologic management of treatment-resistant depression

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Review

A critical overview of the pharmacologic management of treatment-resistant depression

Andrew A Nierenberg et al. Psychiatr Clin North Am. 2007 Mar.

Abstract

Major depressive disorder is a frequent, serious disorder that usually responds partially to treatment and leaves many patients with treatment resistance. This article reviews and critically evaluates the evidence for the management of treatment-resistant depression and examines pharmacologic approaches to alleviate the suffering of patients who benefit insufficiently from initial treatment.

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