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. 1992 Jan;23(1):53-4.
doi: 10.1016/0167-8140(92)90305-e.

Dose escalation for stage C (T3) prostate cancer: minimal rectal toxicity observed using conformal therapy

H M Sandler  1 , C Perez-Tamayo, R K Ten Haken, A S Lichter
Affiliations

Dose escalation for stage C (T3) prostate cancer: minimal rectal toxicity observed using conformal therapy

H M Sandler et al. Radiother Oncol. 1992 Jan.

Abstract

The treatment of stage C (T3) adenocarcinoma of the prostate using external beam radiation therapy (RT) reportedly achieves clinical local control of approximately 70-80%. A dose relationship to local control has been demonstrated in prostate cancer, although a dose-related increase in complications has also been observed. To determine the maximum dose deliverable to the prostate gland while maintaining an acceptable complication rate, a prospective dose-escalation trial using a conformational planning and dose-delivery technique was initiated for patients with stage C (T3) disease. Initial results reported here are encouraging.

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