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Comment
. 2007 Jun 1;581(Pt 2):425-7.
doi: 10.1113/jphysiol.2007.131656. Epub 2007 Mar 15.

What have we learned from single ion channels?

David Colquhoun  1
Affiliations
Comment

What have we learned from single ion channels?

David Colquhoun. J Physiol. .
No abstract available

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Figures

Figure 1
Figure 1
A, a typical predicted burst (in this case with 3 openings) based on the fastest binding that was physically feasible (taken as 5 × 108m−1 s−1). R represents the receptor and A the agonist (taken from Fig. 1, Colquhoun & Hawkes, 1977). B, an observed burst of openings (frog endplate, 100 nm suberyldicholine) (taken from Fig. 1, Colquhoun & Sakmann, 1985).
Figure 2
Figure 2
A, Sakmann dissects a cutaneus pectoris while D.C. patches, Göttingen, 1980. B, D.C. and B.S. at home, 11 pm, on 6 March 1985, back from UCL on the day the paper was finished.
See this image and copyright information in PMC

Comment on

References

    1. Burzomato V, Beato M, Groot-Kormelink PJ, Colquhoun D, Sivilotti LG. Single channel behavior of heteromeric α1β glycine receptors: an attempt to detect a conformational change before the channel opens. J Neurosci. 2004;24:10924–10940. - PMC - PubMed
    1. Colquhoun D. Binding, gating, affinity and efficacy. The interpretation of structure activity relationships for agonists and of the effects of mutating receptors. Br J Pharmacol. 1998;125:923–948. - PMC - PubMed
    1. Colquhoun D, Hawkes AG. Relaxation and fluctuations of membrane currents that flow through drug- operated channels. Proc R Soc Lond B Biol Sci. 1977;199:231–262. - PubMed
    1. Colquhoun D, Hawkes AG. On the stochastic properties of bursts of single ion channel openings and of clusters of bursts. Philos Trans R Soc Lond B Biol Sci. 1982;300:1–59. - PubMed
    1. Colquhoun D, Hawkes AG, Merlushkin A, Edmonds B. Properties of single ion channel currents elicited by a pulse of agonist concentration or voltage. Philos Trans R Soc Lond A. 1997;355:1743–1786.

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