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Editorial
. 2007 Apr;127(4):742-4.
doi: 10.1038/sj.jid.5700694.

Tightening the epidermal barrier with atypical PKCs

Mitchell F Denning  1
Affiliations
Free article
Editorial

Tightening the epidermal barrier with atypical PKCs

Mitchell F Denning. J Invest Dermatol. 2007 Apr.
Free article

Abstract

The permeability barrier function of the epidermis is one of the most vital jobs performed by the skin; however, our understanding of the function and regulation of tight junctions in the epidermis remains limited. Helfrich et al. identify a key role for atypical protein kinase C (aPKC) activity, as a component of the Par3-Par6 polarity complex, in epidermal barrier function.

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