Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2007 Apr;8(4):327-31.
doi: 10.1038/sj.embor.7400943. Epub 2007 Mar 16.

Bone morphogenetic proteins: from developmental signals to tissue regeneration. Conference on bone morphogenetic proteins

Petra Simic  1 , Slobodan Vukicevic
Affiliations

Bone morphogenetic proteins: from developmental signals to tissue regeneration. Conference on bone morphogenetic proteins

Petra Simic et al. EMBO Rep. 2007 Apr.
No abstract available

PubMed Disclaimer

Figures

Figure 1
Figure 1
Bone morphogenetic protein signalling. A member of the BMP family induces heterodimeric complex formation between two BMP receptors (BMPRs). The type II receptor kinase phosphorylates the type I receptor and subsequently activates intracellular signalling. On BMPR activation, Smad1–Smad5–Smad8 forms heterodimeric complexes with Smad4, which then translocate to the nucleus where they act directly and/or cooperate with other molecules to regulate the transcription of target genes. Inhibitory Smad6–Smad7 specifically inhibits BMP signalling. Antagonists, stimulatory and inhibitory co-receptors, and Smurfs are actively involved in maintaining the BMP tissue homeostasis and regulate cross-talk with other signalling pathways. ActR, activin receptor; ALK, activin receptor-like kinase; BAMBI, BMP and activin membrane-bound inhibitor; BMP, bone morphogenetic protein; c-kit, CD117, tyrosine kinase receptor; GPI, glycosylphosphatidyl inositol; HJV, haemojuvelin; P, phosphorylation; Ror2, receptor tyrosine kinase-like orphan receptor 2; Smurf, Smad ubiquitin regulatory factor; Tsg, twisted gastrulation; Tyr, tyrosine; USAG1, uterine sensitization-associated gene 1.
Figure 2
Figure 2
Role of bone morphogenetic proteins in tumour biology. Bone morphogenetic protein (BMP) 7 promotes the mesenchyme-to-epithelial transformation (MET), and specifically inhibits the transforming growth factor-β (TGF-β)-mediated epithelium-to-mesenchyme transformation (EMT), both of which inhibit tumour metastasis and growth. Tumour metastatic cells release growth factors that promote bone resorption by osteoclasts. Osteoclasts then release BMPs from the bone matrix, which in turn inhibit tumour growth.
Figure 3
Figure 3
Bone morphogenetic proteins in tissue engineering. Bone morphogenetic proteins (BMPs) inhibit myogenesis, and promote formation of new bones through activating the expression of inhibitor of differentiation (Id) genes, which prevent activity of myoD/myogenin. Scaffolds filled with bone-marrow cells and BMPs are placed into the back muscle of a patient who is in need of a new bone, such as a frontal bone or mandible.
None
Petra Simic
None
Slobodan Vukicevic
None
The Sixth International Conference on Bone Morphogenetic Proteins took place between 11 and 15 October 2006 in Cavtat, Croatia, and was organized by the Croatian Calcified Tissues Society and Zagreb School of Medicine.
See this image and copyright information in PMC

References

    1. Chang SC, Hoang B, Thomas JT, Vukicevic S, Luyten FP, Ryba NJ, Kozak CA, Reddi AH, Moos M Jr (1994) Cartilage-derived morphogenetic proteins. New members of the transforming growth factor-β superfamily predominantly expressed in long bones during human embryonic development. J Biol Chem 269: 28227–28234 - PubMed
    1. Chen C et al. (2003) An integrated functional genomics screening program reveals a role for BMP-9 in glucose homeostasis. Nat Biotechnol 21: 294–301 - PubMed
    1. Hartung A, Sieber C, Knaus P (2006) Yin and Yang in BMP signalling: impact on the pathology of disease and potential for tissue regeneration. Signal Trans 6: 314–328
    1. Hogan BLM (1996) Bone morphogenetic proteins: multifunctional regulators of vertebrate development. Gen Develop 10: 1580–1594 - PubMed
    1. Miyazono K, Maeda S, Imamura T (2005) BMP receptor signalling: transcriptional targets, regulation of signals, and signalling cross-talk. Cytokine Growth Factor Rev 16: 251–263 - PubMed

Publication types

Substances