Alanine peak in central neurocytomas on proton MR spectroscopy

Abstract

Introduction: We present three consecutive patients with central neurocytoma in whom proton MRS demonstrated the presence of alanine.

Materials and methods: Three patients in the age range 24 to 30 years underwent MRI and proton MRS using a 1.5-T system. MRS was performed with the multivoxel PRESS sequence. All three patients underwent surgery and the diagnosis of central neurocytoma was established by histopathological examination and immunostaining.

Results: With an echo time of 135 ms glycine, high choline, small NAA and alanine were observed in all three patients.

Conclusion: Alanine may be observed in central neurocytomas as it is in meningiomas. Other spectral peaks such as those for glycine and NAA should help to identify this tumor correctly.