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Review
. 2007 Jul;27(4):347-62.
doi: 10.1007/s10875-007-9084-0. Epub 2007 Mar 16.

Host innate immune response to Mycobacterium tuberculosis

Kamlesh Bhatt  1 , Padmini Salgame
Affiliations
Review

Host innate immune response to Mycobacterium tuberculosis

Kamlesh Bhatt et al. J Clin Immunol. 2007 Jul.

Abstract

This review focuses on recent progress in our understanding of Mycobacterium tuberculosis survival in macrophages, the interaction of M. tuberculosis with Toll-like receptors (TLRs) and the establishment of the link between innate and adaptive immunity, and TLRs and interferon-gamma-mediated antimicrobial pathways in macrophages. We also propose a paradigm that TLR2 signaling regulates the magnitude of the host Th1 response leading to either M. tuberculosis persistence and latent infection or replication and disease.

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