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. 2007 Mar;40(2):103-7.
doi: 10.1080/08916930601118825.

Celiac disease associated antibodies in persons with latent autoimmune diabetes of adult and type 2 diabetes

J C Sánchez  1 , E Cabrera-Rode, L Sorell, J A Galvan, A Hernandez, G Molina, P A Perich, M E Licea, E Domínguez, O Díaz-Horta
Affiliations
Free article

Celiac disease associated antibodies in persons with latent autoimmune diabetes of adult and type 2 diabetes

J C Sánchez et al. Autoimmunity. 2007 Mar.
Free article

Erratum in

  • Autoimmunity. 2007 May;40(3):234-5. Cruz, Julio Cesar Sánchez [corrected to Sánchez, J C]; Rode, Eduardo Cabrera [corrected to Cabrera-Rode, E]; Gómez, Luis Sorell [corrected to Sorell, L]; Cabrera, José A Galvan [corrected to Galvan, J A]; Ortega, Ania Hernandez [corrected to Hernandez,

Abstract

Background: Celiac Disease (CD) is present in 1-16.4% of patients with type 1 diabetes mellitus. The most important serological markers of CD are anti-endomysial (EMA), anti-tissue transglutaminase (tTGA) and antigliadin antibodies (AGA).

Aim/hypothesis: The objective of this work is to determine the frequency of tTGA and/or AGA in latent autoimmune diabetes of adult (LADA) and subjects with type 2 diabetes (T2DM), as well as to evaluate their relation with several clinical and biochemical characteristics.

Subjects and methods: Forty three subjects with LADA and 99 with T2DM were studied. The presence of AGA, tTGA was determined in the sera of these patients. The variables: sex, age, duration of diabetes, treatment, body mass index (BMI) and fasting blood glucose concentration were also recorded.

Results: No differences were found in the frequency of celiac disease associated antibodies between LADA and T2DM subjects. The presence of celiac disease related antibodies was more frequent in patients with a normal or low BMI.

Conclusions: Celiac disease does not seem to be related with pancreatic autoimmunity in type 2 diabetes. Celiac disease causes a decrease of body mass index in type 2 diabetes while pancreatic islet autoimmunity in this entity masks this effect.

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