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. 2007 Jan-Feb;9(1):13-8.
doi: 10.1080/10286020500289444.

Three major urinary metabolites of sinomenine in rats

W-M Cheng  1 , F Qiu, X-S Yao
Affiliations

Three major urinary metabolites of sinomenine in rats

W-M Cheng et al. J Asian Nat Prod Res. 2007 Jan-Feb.

Abstract

Urinary metabolites of sinomenine were investigated in rats after intragastric administration. Three major metabolites were obtained and characterised as 4-hydroxy-3,7,7-trimethoxy-17-methyl-(9alpha,13alpha,14alpha)-morphinan-6-one (1), 7,8-didehydro-4-hydroxy-3,7-dimethoxy-17-methyl-N-oxide-(9alpha,13alpha,14alpha)-morphinan-6-one (2), and 7,8-didehydro-4-hydroxy-3,7-dimethoxy-(9alpha,13alpha,14alpha)-morphinan-6-one (3). Their structures have been elucidated on the base of spectral analysis, among which 1 and 2 were new compounds.

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