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Case Reports
. 2007;39(1):87-90.
doi: 10.1080/00365540600786564.

Scedosporium prolificans brain abscess in a patient with chronic granulomatous disease: successful combination therapy with voriconazole and terbinafine

Sunil V Bhat  1 , David L Paterson, Michael G Rinaldi, Peter J Veldkamp
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Case Reports

Scedosporium prolificans brain abscess in a patient with chronic granulomatous disease: successful combination therapy with voriconazole and terbinafine

Sunil V Bhat et al. Scand J Infect Dis. 2007.

Abstract

A patient with chronic granulomatous disease developed brain abscesses with Scedosporium prolificans. In vitro susceptibility revealed a synergistic effect of terbinafine and voriconazole. He received therapy with both these antifungals which resulted in disappearance of the brain abscesses. This is the first reported cure of a CNS S. prolificans infection in an immunocompromised host.

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